Best Grants for Global Health in Africa

The Creag Foundation, established in 2009 in Woodinville, Washington, provides funding to innovative 501(c)(3) nonprofit organizations addressing social issues. Focused on smaller organizations, the foundation seeks to support those with unique approaches to improve the human condition. Eligible applicants must have held 501(c)(3) status for at least one year and present a new or previously unaddressed solution to societal challenges. Applications are by invitation only, encouraging creativity and passion in charitable work.

The Draper Richards Kaplan Foundation provides grants to early-stage social entrepreneurs working on scalable solutions to pressing social and environmental issues. By supporting organizations with innovative approaches and proven impact, they aim to uplift underserved communities globally. The foundation offers operational support, funding of up to $300,000 over three years, and fosters a collaborative community among its portfolio organizations. They focus on candidates demonstrating measurable impact and sustainable growth potential.

The Global Fund for Children invites community-based organizations worldwide to partner in improving the lives of children and youth. They seek dynamic groups aligned with their mission, focusing on grassroots solutions to tackle poverty, injustice, and discrimination. With a commitment to education, gender justice, safety, climate resilience, and youth empowerment, GFC builds strong relationships with potential partners, ensuring mutual growth and impact without requiring formal proposals.

The Global Impact Cash Grants by Cisco Systems Foundation support innovative early-stage solutions aimed at addressing significant social problems. Targeting nonprofit and nongovernmental organizations, these grants focus on four key sectors: crisis response, education, economic empowerment, and climate regeneration. Eligible organizations must demonstrate alignment with these areas, particularly serving underserved communities. The foundation seeks to leverage technology for impactful solutions, ensuring sustainability and community resilience through strategic investments.

The MacFarlane Foundation, established in 2009, is dedicated to enhancing the quality of life for individuals and communities through strategic grantmaking. It supports U.S. public charities focused on education, economic empowerment, climate change, health, and women's well-being. Grants range from $10,000 to $250,000, with a commitment to fostering growth in organizations. The foundation invites proposals annually, ensuring impactful contributions to various causes both domestically and internationally.

The One by One Program Grant, offered by 4Imprint, provides support to organizations making a difference in their communities. Each business day, three selected organizations receive $500 in promotional products to aid their efforts. Eligible applicants include 501(c)3 charities, religious organizations, and accredited schools. Applications must be submitted two months prior to the event, and organizations can apply only once every 12 months. This initiative embodies a commitment to small, impactful contributions.

The RNP Foundation Grant focuses on enhancing the well-being of underserved communities through education, nutrition, housing, and environmental care. The foundation seeks partnerships with like-minded nonprofits to collaboratively address issues such as homelessness and promote spiritual growth. With a commitment to sustainable development, the RNP Foundation aims to create lasting happiness and security for all individuals, ensuring that basic needs are met before fostering personal and communal spirituality.

Roche Corporate Donations and Philanthropy (CDP) focuses on impactful projects that foster sustainable development, engage employees, and leverage Roche's expertise. Their philanthropic efforts prioritize humanitarian, educational, environmental, and cultural initiatives, aiming to build stronger communities and support innovative projects. Eligibility is limited to local organizations, while ineligible projects include those with political or religious ties. The foundation strives to create a positive societal impact through collaboration and strategic partnerships.

The Semnani Family Foundation, established in 1993, is dedicated to supporting marginalized communities worldwide through health, education, and disaster relief initiatives. Founded by Khosrow and Ghazaleh Semnani, it began by funding an orphanage in Romania. The foundation also operates locally, providing free healthcare through the Maliheh Free Clinic in Utah. Its commitment to human welfare drives impactful partnerships in countries such as Afghanistan, India, and South Africa, focusing on the most vulnerable populations.

The Skees Family Foundation offers mission-aligned Seed Grants to nonprofits focused on job creation and readiness, primarily outside the U.S. These grants, beginning at $2,500 and increasing over three years, aim to support organizations with annual budgets of $250,000 or less. By prioritizing international efforts, the foundation seeks to maximize the impact of its limited resources, fostering growth in community-based organizations dedicated to alleviating poverty and promoting economic development globally.

The Audacious Project Grant Program, supported by TED, aims to catalyze social impact by funding bold solutions to pressing global challenges. This initiative encourages changemakers to develop transformative ideas into actionable plans, with a focus on various issues, including health and education. The program operates on a rolling basis, welcoming applications from individuals and organizations with a proven track record and a budget of at least $2 million. Join us in creating lasting change for a better world.

The Zegar Family Foundation Grant, established in 2007, focuses on improving lives through impactful charitable donations. The foundation prioritizes areas such as environment, justice, human rights, science, education, and community development. While unsolicited proposals are not accepted, the foundation remains open to innovative ideas that align with its mission. Through targeted support, it aims to create lasting positive change in communities and promote social equity.

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For technically ambitious or higher-risk, earlier-stage concepts focused on feasibility testing, assay or workflow prototyping, and initial cost-reduction validation. Intended approaches that require focused development to demonstrate viability.

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For concepts with preliminary feasibility evidence that are ready to advance from prototype toward an integrated workflow—optimizing performance, broadening assay or pathogen coverage, and generating more robust cost-reduction and performance data.

Innovations in Low-Cost and Simplified Pathogen Sequencing Workflows

Catalyzing Innovation through Partnerships

At its core, Grand Challenges catalyzes bold innovation through partnership - bringing together funders, researchers, implementers, and public health leaders to solve complex global challenges. This multi-partner initiative reflects the Grand Challenges ethos, leveraging complementary expertise and investments to accelerate accessible genomic sequencing solutions for low- and middle-income Countries.

About this Challenge

This Grand Challenge is co-funded by the Gates Foundation, and the Temasek Foundation, and will be managed by the United Nations Foundation. This Grand Challenge is implemented in collaboration with a network of global and regional partners, including International Pathogen Surveillance Network (IPSN), hosted by the WHO Hub for Pandemic and Epidemic Intelligence, the Africa Pathogen Genomics Initiative (Africa PGI), and the Asia Pathogen Genomics Initiative (Asia PGI) as regional technical and public-health partners. This RFP aims to accelerate the development of affordable, scalable, and operationally simple sequencing solutions, enabling routine use of genomics for public health in low- and middle-income countries (LMICs).

Award Structure and Funding Level

To accommodate different stages of innovation maturity, this RFP supports a tiered award structure, with funding levels and expectations aligned to the readiness and scope of the proposed work. Indicative award categories are:

For more mature concepts aimed at workflow refinement, performance optimization, and generation of proof-of-concept and validation data in relevant public-health use cases in LMICs.

The Dudley T. Dougherty Foundation Grant supports nonprofit charitable organizations recognized under section 501(c)(3) of the IRS Revenue Code. Established in 2002, the foundation aims to empower groups committed to positive change, fostering respect for life and the environment. Their vision emphasizes collaboration for a better future, encouraging applicants to embody these values in their initiatives. With a focus on impactful projects, this grant is an opportunity for organizations striving to make a critical difference in our world.

The Lawrence Foundation is a private family foundation established in 2000, dedicated to granting funds for environmental and human services causes. Eligible organizations include 501(c)(3) nonprofits and public schools, with grants typically ranging from $5,000 to $10,000. The foundation supports unrestricted grants for various projects, including disaster relief and environmental programs, but does not fund individuals or for-profit entities. Applications are evaluated based on alignment with the foundation's priorities.

The Cowles Charitable Trust Grant supports initiatives aligned with the philanthropic legacy of Gardner Cowles, Jr. Focused on education, social justice, health, and the arts, it favors organizations recognized as 501(c)(3) by the IRS. The Trust encourages applications for general operating support and seeks partnerships rather than being the sole funder. Notably, it considers applications from established partners and supports efforts in Downstate New York and South Florida, with a preference for diverse funding sources.

The Tomberg Family Philanthropies supports impactful programs in education, health, environment, and poverty alleviation, focusing on projects that empower communities for sustainable change. They exclusively fund 501(c)(3) nonprofit organizations in the U.S. and seek innovative initiatives that maximize limited resources. Note that grants typically do not cover ongoing operational costs or projects run by religious organizations. Applications for the current funding cycle are open until September 8, 2025.

The CPPS Heritage Mission Fund Grant supports initiatives aligned with Precious Blood Spirituality, focusing on dignity, healing, and community solidarity. Starting in 2026, applications will be accepted once a year, with a two-hour window for Letters of Inquiry. Grants range from $5,000 to $100,000, addressing unmet needs through various project types, including startup support and capital projects. This fund emphasizes the interconnectedness of all life and the importance of serving the common good.

The Dr. Scholl Foundation offers grants annually to IRS 501(c)(3) organizations, primarily focusing on U.S. applicants. The foundation supports projects in education, social services, healthcare, civic and cultural initiatives, and environmental efforts. While the grant cycle runs from October 1 to March 1, it encourages innovative solutions to global challenges. Only one application per organization is accepted each year, and funding is limited to one year. Unqualified organizations, including political entities, are ineligible.

NextWorldNow Community Investments aims to enhance community well-being through targeted funding for development projects. By supporting local initiatives, they ensure measurable social impact while fostering sustainable solutions. Their approach prioritizes direct engagement with communities, minimizing overhead to maximize the flow of resources. With a commitment to accountability and innovation, NWN invites proposals from diverse geographies, focused on long-term benefits for the communities. They believe small changes can lead to significant transformations, addressing unmet global needs.

The Hansen Family Foundation Grant seeks to empower organizations that uphold the American values of life, liberty, and the pursuit of happiness. Focused on diverse causes like children, education, animals, environmental conservation, humanitarian efforts, and arts, the foundation is committed to supporting initiatives that create positive change. Eligible applicants must be 501(c)(3) nonprofits, while political campaigns and organizations with high budgets or overheads are ineligible. This grant fosters impactful contributions to society.

The International Foundation Grant is aimed at U.S.-based non-profit organizations working in developing countries to enhance health, education, and income levels for impoverished communities. While currently not accepting new applications, the foundation reviews proposals from previously invited organizations. The focus lies on holistic, community-driven projects in sectors such as agriculture, education, environment, and health. Partnerships with local entities are encouraged to ensure sustainable and impactful outcomes.

The .ORG Impact Awards, organized by the Public Interest Registry, honor individuals and organizations connected to .ORG domains for their impactful contributions in areas such as health, education, diversity, and environmental stewardship. Participants can receive up to $50,000 for their chosen non-profit and gain visibility through various promotional platforms. This initiative not only recognizes excellence but also fosters community support and encourages innovative solutions to pressing societal issues.

The KFAS: Al-Sumait Prize for Health recognizes groundbreaking contributions to food security, health, and education in Africa. This prestigious award, established in honor of Dr. Abdulrahman Al-Sumait, seeks nominations for individuals or institutions that have made significant advancements in various fields, including sustainable agriculture and innovative health solutions. The prize aims to celebrate impactful research and initiatives that contribute to the continent's socio-economic development, with nominations open for the 2025 cycle.

The Gupta Family Foundation Grant aims to empower disadvantaged individuals by providing financial support to organizations that foster self-reliance. Headquartered in Herndon, Virginia, the foundation offers grants ranging from $5,000 to over $250,000, prioritizing smaller organizations with a strong commitment to their missions. Eligibility typically includes US-based IRS 501(c)(3) entities, with operations extending to countries like India and Kenya. The foundation emphasizes mission alignment and effective resource allocation to ensure maximum impact.