Best Large Grants for Nonprofit Organizations in Africa

The Big G Charitable Foundation, founded in 2009 by Mike Galesi, is dedicated to supporting environmental conservation and emergency relief efforts. Inspired by his father, John (Big G), Mike's commitment to helping others drives the foundation's mission to protect the defenseless and promote sustainability. Through grants, the foundation aids qualified non-profit organizations focused on these critical areas, ensuring that both our planet and those in crisis receive the support they need.

The Brutten Family Foundation Grant focuses on enhancing access to the outdoors, quality education, and mental health services. Established in 1996, the foundation supports organizations that align with its core pillars: environment, education, and mental health. By nurturing local and global initiatives, the foundation aims to inspire the next generation of stewards for a healthier planet. They welcome applications from 501(c)(3) organizations worldwide committed to making a positive impact.

The Draper Richards Kaplan Foundation provides grants to early-stage social entrepreneurs working on scalable solutions to pressing social and environmental issues. By supporting organizations with innovative approaches and proven impact, they aim to uplift underserved communities globally. The foundation offers operational support, funding of up to $300,000 over three years, and fosters a collaborative community among its portfolio organizations. They focus on candidates demonstrating measurable impact and sustainable growth potential.

The Global Fund for Children invites community-based organizations worldwide to partner in improving the lives of children and youth. They seek dynamic groups aligned with their mission, focusing on grassroots solutions to tackle poverty, injustice, and discrimination. With a commitment to education, gender justice, safety, climate resilience, and youth empowerment, GFC builds strong relationships with potential partners, ensuring mutual growth and impact without requiring formal proposals.

The MacFarlane Foundation, established in 2009, is dedicated to enhancing the quality of life for individuals and communities through strategic grantmaking. It supports U.S. public charities focused on education, economic empowerment, climate change, health, and women's well-being. Grants range from $10,000 to $250,000, with a commitment to fostering growth in organizations. The foundation invites proposals annually, ensuring impactful contributions to various causes both domestically and internationally.

The Michael & Susan Dell Foundation provides grants to organizations focused on improving the lives of children in urban poverty in the U.S., India, and South Africa. They prioritize projects in education, health, and family economic stability. Grants typically do not exceed 25% of a project's budget or 10% of an organization's annual expenses. The foundation seeks to partner with organizations already making an impact, ensuring funding supports impactful social enterprises.

The Pentair Foundation, a corporate philanthropy initiative, focuses on creating sustainable communities through water solutions and STEM education. With over $80 million in contributions since 1998, the foundation emphasizes ecological resilience, water quality improvement, and youth engagement in science and technology. They prioritize grantmaking in specific U.S. states and international regions, fostering vibrant communities and encouraging employee volunteerism. Initiatives are invitation-only, ensuring a targeted approach to impactful philanthropy.

The RNP Foundation Grant focuses on enhancing the well-being of underserved communities through education, nutrition, housing, and environmental care. The foundation seeks partnerships with like-minded nonprofits to collaboratively address issues such as homelessness and promote spiritual growth. With a commitment to sustainable development, the RNP Foundation aims to create lasting happiness and security for all individuals, ensuring that basic needs are met before fostering personal and communal spirituality.

Roche Corporate Donations and Philanthropy (CDP) focuses on impactful projects that foster sustainable development, engage employees, and leverage Roche's expertise. Their philanthropic efforts prioritize humanitarian, educational, environmental, and cultural initiatives, aiming to build stronger communities and support innovative projects. Eligibility is limited to local organizations, while ineligible projects include those with political or religious ties. The foundation strives to create a positive societal impact through collaboration and strategic partnerships.

The Rotary Club's Global Grants initiative supports significant international projects that yield sustainable results. By collaborating with local communities, Rotary clubs and districts address pressing needs across various focus areas, including health, education, and economic development. These grants, with budgets ranging from $30,000 to $400,000, enable clubs to implement impactful humanitarian projects, scholarships, and vocational training, ultimately fostering global partnerships and enhancing community welfare.

The Sachs Family Foundation Grant aims to enhance the quality of life for economically and educationally disadvantaged individuals and families. The Foundation supports self-sustaining charitable organizations focusing on economic and educational opportunities, particularly in low-income communities in the U.S. and developing countries. Grants are available for various initiatives, including education, housing, and job training, with a keen interest in programs that demonstrate clear potential for sustainability.

The Semnani Family Foundation, established in 1993, is dedicated to supporting marginalized communities worldwide through health, education, and disaster relief initiatives. Founded by Khosrow and Ghazaleh Semnani, it began by funding an orphanage in Romania. The foundation also operates locally, providing free healthcare through the Maliheh Free Clinic in Utah. Its commitment to human welfare drives impactful partnerships in countries such as Afghanistan, India, and South Africa, focusing on the most vulnerable populations.

The Audacious Project Grant Program, supported by TED, aims to catalyze social impact by funding bold solutions to pressing global challenges. This initiative encourages changemakers to develop transformative ideas into actionable plans, with a focus on various issues, including health and education. The program operates on a rolling basis, welcoming applications from individuals and organizations with a proven track record and a budget of at least $2 million. Join us in creating lasting change for a better world.

The Walmart Foundation invites 501(c)(3) organizations to submit program-related concept notes focused on the Healthier Food for All initiative. This ongoing program seeks to enhance access to nutritious food in underserved communities while linking nutrition to healthcare. With a commitment to combat chronic illnesses through better nutrition, Walmart aims to fill food access gaps and promote food as medicine programs, ultimately improving health outcomes for many Americans.

The Zegar Family Foundation Grant, established in 2007, focuses on improving lives through impactful charitable donations. The foundation prioritizes areas such as environment, justice, human rights, science, education, and community development. While unsolicited proposals are not accepted, the foundation remains open to innovative ideas that align with its mission. Through targeted support, it aims to create lasting positive change in communities and promote social equity.

The Gupta Family Foundation Grant aims to empower disadvantaged individuals by providing financial support to organizations that foster self-reliance. Headquartered in Herndon, Virginia, the foundation offers grants ranging from $5,000 to over $250,000, prioritizing smaller organizations with a strong commitment to their missions. Eligibility typically includes US-based IRS 501(c)(3) entities, with operations extending to countries like India and Kenya. The foundation emphasizes mission alignment and effective resource allocation to ensure maximum impact.

The iF SOCIAL IMPACT PRIZE aims to support impactful projects addressing pressing societal challenges, awarding a total of EUR 100,000 annually. Open to diverse organizations, including NGOs and social enterprises, the prize recognizes initiatives that align with the 15 UN Sustainable Development Goals. Projects should be already implemented and demonstrate relevance, ethical standards, and positive impacts. Selected projects gain exposure in a global design community, enhancing visibility without cost or time limitations.

The Zimmer Family Foundation provides national and international grants to support religious, educational, and social programs aimed at assisting the less fortunate. Based in Sarasota, Florida, the foundation focuses on seeding short-term pilot projects with potential for self-sustainability. Eligible applicants must be 501(c)(3) IRS Tax exempt organizations, with projects that can be national or international in scope. The foundation does not fund scholarships, capital purchases, or operating support.

The Moderna Charitable Foundation, established in 2022, aims to enhance public health and healthcare access while fostering scientific education and inclusion in underserved communities. Their initiatives include grant-making to aligned organizations, supporting humanitarian crises, and employee matching for personal causes. The Foundation focuses on building resilient health ecosystems, advancing STEM education, and addressing systemic barriers in communities, all while committed to addressing the ongoing impact of COVID-19.

The Exploring Equitable Futures Grant Program, funded by the Robert Wood Johnson Foundation, aims to transform health equity by addressing systemic racism. It supports innovative thinkers across various fields to envision a future where health is a right for all. By exploring social, technological, and economic trends, grantees are developing solutions that challenge existing barriers to health, fostering inclusive and accountable public health systems that benefit everyone in society.

Delta Analytics offers the Data Service Grant to empower non-profits with data-driven insights. This opportunity, which extends applications until November 14, 2025, aims to enhance community impact through effective data management, analysis, and visualization. By partnering skilled data scientists with organizations, Delta facilitates the transformation of complex data into actionable strategies, ensuring that nonprofits can measure their impact and optimize their operations. Interested 501(c)(3) organizations are encouraged to apply.

The Dudley T. Dougherty Foundation Grant supports nonprofit charitable organizations recognized under section 501(c)(3) of the IRS Revenue Code. Established in 2002, the foundation aims to empower groups committed to positive change, fostering respect for life and the environment. Their vision emphasizes collaboration for a better future, encouraging applicants to embody these values in their initiatives. With a focus on impactful projects, this grant is an opportunity for organizations striving to make a critical difference in our world.

The Versafund Grant Program: Impact Grant, offered by the Versacare Foundation, provides funding between $40,001 and $100,000 to eligible Seventh-day Adventist organizations. This grant supports innovative projects addressing community engagement, education, health, and humanitarian efforts. Applicants must demonstrate proven successful practices and creativity in delivering services to underserved populations. The foundation prioritizes projects in North America and the Inter-American Division, emphasizing social justice and support for women, children, and youth.

The John Templeton Foundation Grant Program aims to inspire awe and wonder through interdisciplinary research and public engagement. By funding bold ideas that challenge conventional thought, the foundation fosters curiosity and understanding. It supports various funding areas, including character virtue development, individual freedom, life sciences, and public engagement. The foundation seeks to create a world where individuals pursue meaningful lives, motivated by love and a desire for knowledge.

The CPPS Heritage Mission Fund Grant supports initiatives aligned with Precious Blood Spirituality, focusing on dignity, healing, and community solidarity. Starting in 2026, applications will be accepted once a year, with a two-hour window for Letters of Inquiry. Grants range from $5,000 to $100,000, addressing unmet needs through various project types, including startup support and capital projects. This fund emphasizes the interconnectedness of all life and the importance of serving the common good.

The New Earth Foundation Grant aims to support innovative, humanitarian projects that promote sustainability, peace, and community development. Founded by John B. Loveland in 1997, the foundation focuses on assisting smaller 501(c)(3) organizations to create impactful solutions for societal challenges. Grants are awarded to projects that demonstrate innovation, community involvement, and the potential for replication, ensuring a lasting positive impact on both local and global scales.

The Zayed Sustainability Prize is a prestigious global award established in 2008, recognizing impactful sustainability solutions in health, food, energy, and water. It honors the legacy of Sheikh Zayed bin Sultan Al Nahyan, promoting innovation and inspiring organizations to advance sustainable practices. Eligible participants include SMEs and non-profits, while early-stage projects and those without demonstrated impact are excluded. This award aims to foster a sustainable future through innovative solutions and long-term vision.