Best Grants for Rare Diseases in Puerto Rico

Nonprofit 501(c)(3) organizations in Puerto Rico supporting children, education, or health and human services may be eligible for charitable contributions to strengthen their community programs. Costco Foundation supports evidence-based initiatives with measurable outcomes and broad financial backing; local groups addressing rare or chronic respiratory conditions within these priorities may benefit.

Nonprofit 501(c)(3) organizations with innovative approaches to human and social services, health, or related societal issues can seek funding to develop or expand new solutions, including work in Puerto Rico. Grants from Creag Foundation help smaller or evolving programs test new models that may benefit people affected by rare or under-addressed diseases.

The Global Impact Cash Grants by Cisco Systems Foundation support innovative early-stage solutions aimed at addressing significant social problems. Targeting nonprofit and nongovernmental organizations, these grants focus on four key sectors: crisis response, education, economic empowerment, and climate regeneration. Eligible organizations must demonstrate alignment with these areas, particularly serving underserved communities. The foundation seeks to leverage technology for impactful solutions, ensuring sustainability and community resilience through strategic investments.

Educational institutions, government programs, 501(c)(3) nonprofits, and 501(c)(4) volunteer fire companies can seek State Farm support for safety, education, and community development initiatives, including in Puerto Rico. State Farm Companies Foundation funds projects such as auto and home safety, disaster preparedness and recovery, affordable housing, job training, financial literacy, and K-16 academic and career success.

Nonprofit cultural institutions in the U.S. offering arts, science, or STEAM programs can seek more than US $100,000 for program, capital, or limited general support, including those serving Puerto Rico. With a mission to strengthen cultural access, Hearst Foundation provides support to museums, theaters, symphonies, arts schools, and similar organizations, including those reaching underserved populations that may be affected by rare diseases.

With a mission to support strong social service programs, nonprofits in Puerto Rico can seek major grants from the William Randolph Hearst Foundation for program, capital, or general support. U.S.-based 501(c)(3) organizations with audited expenses over $2 million working on poverty, housing, food access, or related services may be eligible for awards over More than US $100,000.

The Labcorp Charitable Foundation, a private 501(c)(3) entity, aims to enhance healthcare access and education for all. With grant opportunities focusing on food programs, healthcare services for underserved populations, and STEM initiatives, it seeks to support community health and well-being. Organizations eligible for funding must be U.S.-based and hold tax-exempt status. Requests are reviewed biannually, in March and September, to foster impactful community projects.

Organizations working on education, children’s health, or family economic stability projects in Puerto Rico may be eligible if their work serves urban low-income children in the U.S. and meets size and focus criteria. Grants from Michael & Susan Dell Foundation support project implementation or scaling, with awards of more than US $50,000 for aligned initiatives.

Accredited charities running humanitarian, social development, science education, community, environmental, or arts programs can apply for Roche’s Corporate Donations and Philanthropy support, including organizations in Puerto Rico. Funding prioritizes innovative, sustainable projects that may benefit rare disease communities and can actively involve Roche expertise, logistics, and employees in cultural, educational, or social activities.

Nonprofits and humanitarian organizations working on health, education, or disaster relief can seek support for marginalized communities worldwide, including Puerto Rico. Grants from Semnani Family Foundation help programs addressing healthcare access, disease, child and women’s health, and humanitarian services, which may benefit initiatives serving people with rare or complex conditions.

U.S.-based 501(c)(3) charitable, scientific, medical, and educational organizations, including those serving Puerto Rico, can apply for the Sidney Stern Memorial Trust’s broad program support. Funding must be used within the U.S. and may benefit nonprofits addressing respiratory or other rare diseases through research, treatment, or related services.

Puerto Rico nonprofits and aligned for-profit organizations working in preservation, education, or wellness can access funding through Jesse W Couch Charitable Foundation to tell powerful stories about their impact. This national Storytelling Grant supports 501(c)(3)s and similar groups, which may include organizations addressing rare or respiratory diseases within the foundation’s program areas.

The Robinson Foundation Grant, established in 2016, aims to alleviate hardships faced by individuals and communities, demonstrating God's love through charitable contributions. As a family-operated foundation, it focuses on creating meaningful, long-term impacts in various areas including animal welfare, education, and disaster relief. Organizations eligible for funding must be 501(c)(3) public charities. The foundation prioritizes fiscally responsible projects with the potential for tangible results, while not supporting capital projects.

Nonprofit 501(c)(3) organizations working on community services, environmental conservation, or peacebuilding in Puerto Rico may be eligible for flexible project or program support. Focused on broad social and environmental impact, the Dudley T Dougherty Foundation invites applicants whose work could intersect with health or rare disease challenges in their communities.

Nonprofit 501(c)(3) organizations supporting basic needs, at-risk youth, or domestic violence services near TJX locations, including Puerto Rico, can seek program funding through The Tjx Foundation. With a mission to help vulnerable families and children build better futures, TJX Foundation provides grants for basic needs, education and training, patient care, and empowering women programs.

Nonprofit 501(c)(3) organizations, public schools, and libraries in Puerto Rico working on environmental or human services programs can apply for the Lawrence Foundation’s unrestricted grants, typically US $5,000 - US $10,000. Funding can support general operating or project costs, which may help organizations serving people affected by rare or chronic diseases.

Nonprofit organizations in Puerto Rico can seek funding for community-based programs, including cultural, educational, health, environmental, and social services projects. Max and Victoria Dreyfus Foundation provides U.S. nonprofits with US $1,000 - US $20,000 to support museums, schools, hospitals, youth and senior services, disability programs, environmental and wildlife efforts, and related initiatives that can benefit rare disease communities.

The Spark Good: Strengthening Community Local Grants program by the Wal-Mart Foundation empowers local organizations through grants ranging from $250 to $5000. This initiative aims to enhance community welfare by supporting diverse projects, including animal shelters and educational programs. Eligible organizations must have a verified Spark Good account, ensuring funds are allocated effectively to meet local needs and foster community development. Together, we can create lasting impacts through small yet significant actions.

Nonprofit 501(c)(3) organizations working on health, education, social justice, or arts initiatives in Puerto Rico can seek funding for programs or general operating support. With a mission to further Gardner Cowles Jr.’s philanthropic legacy, Cowles Charitable Trust provides up to US $10,000, occasionally supporting mission-aligned national and international efforts, including medical and climate research that may intersect with rare disease work.

Nonprofit 501(c)(3) organizations in Puerto Rico working on basic needs, community vitality, or volunteer-driven programs may be eligible for Ameriprise Financial Community Grants. Grants from Ameriprise Financial help U.S. nonprofits address hunger, shelter, housing stability, financial literacy, workforce readiness, and culturally enriching community development that could benefit people with rare diseases.

Puerto Rico 501(c)(3) nonprofits providing basic needs or economic mobility opportunities for youth and families can access funding through Nordstrom, with awards ranging from US $5,000 - US $20,000. Organizations serving communities near Nordstrom store locations may be eligible, and unrestricted grants can support local programs addressing food, shelter, clothing, or workforce development.

Health and social service nonprofits in Puerto Rico can seek project-based funding for education, health care, social services, civic and cultural, or environmental initiatives. Dr Scholl Foundation supports 501(c)(3) organizations, primarily in the U.S., with grants ranging from US $5,000 - US $25,000 for one year of funding.

U.S.-based 501(c)(3) nonprofits addressing children’s services, education, humanitarian aid, or related programs in Puerto Rico can apply for Hansen Family Foundation grants of US $1,000 - US $10,000. Organizations working on rare disease support within these areas may be eligible if they meet the foundation’s mission and budget and overhead limits.

Nonprofit 501(c)(3) organizations improving health, economic stability, or basic needs can seek project, operating, or capital support that benefits local communities where O’Reilly Auto Parts operates, including Puerto Rico. With a mission to strengthen underserved individuals and families, O'Reilly Automotive Foundation provides funding for health and social services, workforce development, poverty relief, and disaster response initiatives.

Nonprofit 501(c)(3) organizations with programs for youth and families, food insecurity, housing, or environmental stewardship in Puerto Rico can apply for US $30,000 - US $350,000 grants. Chick Fil A Foundation’s True Inspiration Awards fund initiatives like academic enrichment, youth leadership, family services, food access, and community or environmental projects that may benefit those affected by rare diseases.

Nonprofit organizations with strong community partnership programs in Puerto Rico and across the U.S. can apply for Mutual of America Foundation’s Community Partnership Award to recognize exemplary collaborative leadership. This national competition honors partnerships that measurably improve communities, can be replicated elsewhere, and introduce innovative approaches to significant social issues, which may include rare or respiratory diseases.

Non-sectarian nonprofits addressing poverty, disability, social disadvantage, or disaster relief can apply for Gupta Family Foundation grants of US $5,000 - US $250,000. The foundation supports smaller, founder-led organizations worldwide, primarily 501(c)(3)s or qualifying foreign entities, whose programs help disadvantaged people become self-reliant and may include work related to rare or chronic conditions.