Browse Grants /
South Carolina /
Large Grants for Nonprofit Organizations in South Carolina

Search Through Large Grants for Nonprofit Organizations in South Carolina in the U.S.

Find the perfect Large Grants for Nonprofit Organizations in South Carolina on Instrumentl. 100+ Large Grants for Nonprofit Organizations in South Carolina in the United States

100+
Available grants

$11.1M
Total funding amount

$11K
Median grant amount

Skip the search.

Get matched with grants that actually fit.

Smart recommendations based on your profile — in minutes.

Find me grants

Last updated: February 2, 2026. Next update: March 1, 2026.

Rolling deadline

Unspecified amount

The Costco Wholesale Charitable Contributions program prioritizes support for children, education, and health services within local communities. Nonprofit organizations seeking assistance must be 501(c)(3) certified and focus on monetary requests. Applications are reviewed within 4-6 weeks, factoring in community needs and collaboration. However, Costco limits grants to 10% of the program budget and typically restricts organizations to one request per fiscal year. They do not fund individuals or direct aid for various specific purposes.

Rolling deadline

Unspecified amount

The Creag Foundation, established in 2009 in Woodinville, Washington, provides funding to innovative 501(c)(3) nonprofit organizations addressing social issues. Focused on smaller organizations, the foundation seeks to support those with unique approaches to improve the human condition. Eligible applicants must have held 501(c)(3) status for at least one year and present a new or previously unaddressed solution to societal challenges. Applications are by invitation only, encouraging creativity and passion in charitable work.

Rolling deadline

Unspecified amount in in-kind support

CSX Charitable Investments provide essential in-kind donations to nonprofit organizations focused on supporting military members and community first responders. Through intermodal transportation services, CSX offers equipment and rail services to help reduce transportation costs for eligible organizations. The program also includes occasional donations of railroad materials and equipment based on availability. CSX prioritizes support for organizations operating within its service areas, promoting community betterment and development.

Rolling deadline

Up to US $300,000

The Draper Richards Kaplan Foundation provides grants to early-stage social entrepreneurs working on scalable solutions to pressing social and environmental issues. By supporting organizations with innovative approaches and proven impact, they aim to uplift underserved communities globally. The foundation offers operational support, funding of up to $300,000 over three years, and fosters a collaborative community among its portfolio organizations. They focus on candidates demonstrating measurable impact and sustainable growth potential.

Rolling deadline

Unspecified amount

The Labcorp Charitable Foundation, a private 501(c)(3) entity, aims to enhance healthcare access and education for all. With grant opportunities focusing on food programs, healthcare services for underserved populations, and STEM initiatives, it seeks to support community health and well-being. Organizations eligible for funding must be U.S.-based and hold tax-exempt status. Requests are reviewed biannually, in March and September, to foster impactful community projects.

Rolling deadline

More than US $50,000

The Michael & Susan Dell Foundation provides grants to organizations focused on improving the lives of children in urban poverty in the U.S., India, and South Africa. They prioritize projects in education, health, and family economic stability. Grants typically do not exceed 25% of a project's budget or 10% of an organization's annual expenses. The foundation seeks to partner with organizations already making an impact, ensuring funding supports impactful social enterprises.

Rolling deadline

Unspecified amount

The Milbank Foundation, established in 1995, focuses on integrating people with disabilities into society. Its current priorities include community-based initiatives for empowerment, rehabilitation of veterans, support for seniors in aging at home, and health care reforms. The Foundation also addresses mental health and substance abuse, particularly among youth. Eligible organizations must be U.S.-based and tax-exempt, while individuals and certain projects, like annual appeals and international initiatives, are ineligible for funding.

Rolling deadline

Unspecified amount

The PNC Foundation aims to enhance the lives of individuals in local communities through partnerships with nonprofit organizations. Their focus includes promoting educational opportunities, particularly for early childhood education, and supporting economic development initiatives. Grants are available for organizations that benefit low- to moderate-income families and enhance community growth. The foundation prioritizes programs that foster sustainability and diversity, ensuring a lasting impact on the communities they serve.

Rolling deadline

Unspecified amount

Roche Corporate Donations and Philanthropy (CDP) focuses on impactful projects that foster sustainable development, engage employees, and leverage Roche's expertise. Their philanthropic efforts prioritize humanitarian, educational, environmental, and cultural initiatives, aiming to build stronger communities and support innovative projects. Eligibility is limited to local organizations, while ineligible projects include those with political or religious ties. The foundation strives to create a positive societal impact through collaboration and strategic partnerships.

Rolling deadline

Unspecified amount

The Semnani Family Foundation, established in 1993, is dedicated to supporting marginalized communities worldwide through health, education, and disaster relief initiatives. Founded by Khosrow and Ghazaleh Semnani, it began by funding an orphanage in Romania. The foundation also operates locally, providing free healthcare through the Maliheh Free Clinic in Utah. Its commitment to human welfare drives impactful partnerships in countries such as Afghanistan, India, and South Africa, focusing on the most vulnerable populations.

Rolling deadline

Unspecified amount

The Sidney Stern Memorial Trust Grant supports charitable, scientific, medical, and educational organizations that are 501(c)(3) certified. This private funder emphasizes impactful service to diverse populations without discrimination. Grants must be utilized within the United States and cannot be awarded to individuals, political candidates, or lobbying efforts. The Trust is dedicated to enhancing the general welfare through soundly-managed initiatives that contribute significantly to community needs.

Rolling deadline

Unspecified amount

The Stantec Community Engagement Grant is dedicated to enhancing the quality of life in communities where Stantec operates. Focused on arts, education, environment, and health and wellness, the grant supports initiatives that foster sustainable development and responsible practices. Organizations seeking funding must align with Stantec's values, emphasizing ethical practices and community impact. Preference is given to projects located near Stantec offices, ensuring a more significant local impact through their contributions.

Rolling deadline

Unspecified amount

The Audacious Project Grant Program, supported by TED, aims to catalyze social impact by funding bold solutions to pressing global challenges. This initiative encourages changemakers to develop transformative ideas into actionable plans, with a focus on various issues, including health and education. The program operates on a rolling basis, welcoming applications from individuals and organizations with a proven track record and a budget of at least $2 million. Join us in creating lasting change for a better world.

Rolling deadline

Unspecified amount

The Bank of America Foundation Sponsorship Program aims to enhance economic mobility and social progress in low- and moderate-income communities through partnerships with nonprofit organizations. This initiative focuses on critical areas such as workforce education, basic needs like food and housing, and community development. The Foundation invested $350 million last year and encourages employee volunteerism and giving, supporting nonprofits in various sectors, including arts, culture, and diversity initiatives.

Rolling deadline

Unspecified amount

Wells Fargo Community Giving supports nonprofit organizations focusing on financial health, housing affordability, small business growth, and sustainability. The grant cycle runs from February to October, inviting organizations with 501(c)(3) status or equivalent to apply. Funding is prioritized for programs addressing critical community needs, while limited support is available for local initiatives like disaster relief and arts. Organizations must demonstrate fiscal stability and potential impact to be considered for funding.

Applications due Mar 27, 2026

More than US $50,000

The J.W. Couch Foundation Grant focuses on supporting Wildlife Conservation nonprofit organizations that align with their mission of community betterment and environmental protection. The foundation seeks partnerships with organizations that promote animal wellbeing, early childhood education, teacher support, and outdoor activities. Eligible applicants must be registered 501(c)3 nonprofits or for-profit entities aligned with their charitable programs. This grant emphasizes collaboration and community engagement to create lasting impacts.

Applications due Mar 30, 2026

More than US $10,000

The Spinks Family Foundation provides large grants of $10,000 and above annually to support non-profit organizations focused on education, food security, health, and mental health initiatives. Organizations must be 501(c)3 certified and demonstrate community impact with at least 500 volunteer hours. Applications are accepted from March 1 to March 30, and awards are announced by September 15. This initiative aims to empower nonprofits to effectively address pressing community needs.

Applications due Mar 31, 2026

More than US $1,000

The Corporate Giving Program by the Franklin P. and Arthur W. Perdue Foundation supports nonprofit organizations that enhance community welfare. Focus areas include agriculture, education, fighting hunger, and public safety. Eligible applicants must have IRS 501(c)(3) status and a Taxpayer Identification number. Requests are prioritized for programs directly benefiting communities near Perdue facilities across various states. The foundation emphasizes responsible stewardship and community engagement in all funding decisions.

Applications due Mar 31, 2026

Unspecified amount

The O'Reilly Automotive Foundation Grant focuses on enhancing community welfare through philanthropic initiatives that support economic stability, workforce development, health services, and disaster relief. Established in 2020, the Foundation seeks to empower underrepresented individuals and organizations in the U.S. by addressing vital community needs. It particularly aims to provide assistance to nonprofits that foster positive change and improve quality of life for those in need, ensuring a lasting impact in local communities.

Applications due May 1, 2026

US $30,000 - US $350,000

The True Inspiration Awards, established by Chick-fil-A in 2015, recognizes nonprofit organizations that significantly impact their communities. In 2025, the program will distribute $6 million in grants, ranging from $30,000 to $350,000, to sixteen selected organizations. Categories include Caring for People, Caring through Food, Community, and Caring for our Planet, with a focus on educational initiatives, food security, housing services, and environmental stewardship, honoring the legacy of founder S. Truett Cathy.

Applications due May 15, 2026

Unspecified amount

The Robinson Foundation Grant, established in 2016, aims to alleviate hardships faced by individuals and communities, demonstrating God's love through charitable contributions. As a family-operated foundation, it focuses on creating meaningful, long-term impacts in various areas including animal welfare, education, and disaster relief. Organizations eligible for funding must be 501(c)(3) public charities. The foundation prioritizes fiscally responsible projects with the potential for tangible results, while not supporting capital projects.

Applications due Jul 1, 2026

Unspecified amount

The Mutual of America Foundation Community Partnership Award honors exemplary nonprofit organizations in the U.S. that foster collaborative partnerships across sectors. Annually, a national competition showcases numerous organizations demonstrating impactful community partnerships. Six organizations receive recognition, including the Thomas J. Moran Award, which offers $100,000, and the Frances R. Hesselbein Award, granting $75,000. Since 1996, the award has acknowledged 262 partnerships, emphasizing Mutual of America's commitment to societal improvement through collaboration.

Applications due Aug 31, 2026

US $5,000 - US $250,000

The Gupta Family Foundation Grant aims to empower disadvantaged individuals by providing financial support to organizations that foster self-reliance. Headquartered in Herndon, Virginia, the foundation offers grants ranging from $5,000 to over $250,000, prioritizing smaller organizations with a strong commitment to their missions. Eligibility typically includes US-based IRS 501(c)(3) entities, with operations extending to countries like India and Kenya. The foundation emphasizes mission alignment and effective resource allocation to ensure maximum impact.

Applications due Oct 16, 2026

Unspecified amount

Insperity's Corporate Contributions program emphasizes community involvement and corporate citizenship, providing philanthropic grants and event sponsorships to 501(c)(3) nonprofit organizations. Eligible organizations must engage Insperity employees or contribute to the communities where they operate. The program aims to support nonprofits in achieving their service goals and enhancing community welfare. Applications must be submitted 90 days prior to events, and funding requests can be made once a year.

Applications due Oct 31, 2026

Unspecified amount

The Dudley T. Dougherty Foundation Grant supports nonprofit charitable organizations recognized under section 501(c)(3) of the IRS Revenue Code. Established in 2002, the foundation aims to empower groups committed to positive change, fostering respect for life and the environment. Their vision emphasizes collaboration for a better future, encouraging applicants to embody these values in their initiatives. With a focus on impactful projects, this grant is an opportunity for organizations striving to make a critical difference in our world.

Applications due Oct 31, 2026

Unspecified amount

The Georgia-Pacific Foundation Grant supports organizations in the Metro Atlanta area, focusing on education, entrepreneurship, community enrichment, and environmental sustainability. Established in 1958, the foundation prioritizes investments that align with its mission and values, promoting long-term well-being within communities where Georgia-Pacific operates. Eligible applicants include 501(c)(3) nonprofits, public schools, and local government entities located within 30 miles of GP manufacturing sites.

Letter of inquiry due Oct 31, 2026

Unspecified amount

The TJX Foundation Grants support nonprofit organizations located within 15 miles of a TJX store that align with their community mission. Eligible areas include basic needs, education for at-risk youth, workforce training, and safety from domestic violence. Organizations must be a registered 501(c)(3) for at least 12 months and have a nondiscrimination policy. Applications are invited through a Letter of Inquiry, with funding decisions based on community impact.

Showing 27 of 100+ results.

Top Searched Large Grants for Nonprofit Organizations in South Carolina

Large Grants for Nonprofit Organizations in South Carolina from Private Funders

Large Grants for Nonprofit Organizations in South Carolina over $20k

Large Grants for Nonprofit Organizations in South Carolina from Government Funders

Grant Insights : Large Grants for Nonprofit Organizations in South Carolina

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Large Grants for Nonprofit Organizations in South Carolina grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

39 Large Grants for Nonprofit Organizations in South Carolina over $25K in average grant size

30 Large Grants for Nonprofit Organizations in South Carolina over $50K in average grant size

30 Large Grants for Nonprofit Organizations in South Carolina supporting general operating expenses

100+ Large Grants for Nonprofit Organizations in South Carolina supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations in South Carolina?

Most grants are due in the first quarter.

28.8%

24.5%

22.2%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations in South Carolina?

Grants are most commonly $11,000.

$500 $500 Min.

$11,000 $11 K Median

$120,746 $120.7 K Average

$5,000,000 $5 M Max.

Average Grant Size

What's the typical amount funded for South Carolina?

Grants are most commonly $79,072.

$79,072

Total Number of Grants

What's the total number of grants in Large Grants for Nonprofit Organizations in South Carolina year over year?

In 2024, funders in South Carolina awarded a total of 9,758 grants.

2022 21,855

2023 21,722

2024 9,758

Top Grant Focus Areas

Among all the Large Grants for Nonprofit Organizations in South Carolina given out in South Carolina, the most popular focus areas that receive funding are Education, Philanthropy, Voluntarism & Grantmaking Foundations, and Human Services.

1. Education

2. Philanthropy, Voluntarism & Grantmaking Foundations

3. Human Services

Funding Over Time

How is funding for Large Grants for Nonprofit Organizations in South Carolina changing over time?

Funding has increased by -48.16%.

2022 $1,534,818,247

2023 $1,485,349,233
-3.22%

2024 $770,073,013
-48.16%

South Carolina Counties That Receive the Most Funding

How does grant funding vary by county?

Greenville County, Richland County, and Spartanburg County receive the most funding.

County	Total Grant Funding in 2024
Greenville County	$307,710,725
Richland County	$209,083,333
Spartanburg County	$126,415,219
Pickens County	$98,462,262
Charleston County	$84,899,163

Search Through Large Grants for Nonprofit Organizations in South Carolina in the U.S.

100+ Available grants

$11.1M Total funding amount

$11K Median grant amount

Skip the search.

Get matched with grants that actually fit.

Get new Large for Nonprofit Organizations in South Carolina grants weekly

La Roche, Inc.

Stantec

TED

Insperity

Top Searched Large Grants for Nonprofit Organizations in South Carolina

Grant Insights : Large Grants for Nonprofit Organizations in South Carolina

Grant Availability

100+ Large Grants for Nonprofit Organizations in South Carolina grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

39 Large Grants for Nonprofit Organizations in South Carolina over $25K in average grant size

30 Large Grants for Nonprofit Organizations in South Carolina over $50K in average grant size

30 Large Grants for Nonprofit Organizations in South Carolina supporting general operating expenses

100+ Large Grants for Nonprofit Organizations in South Carolina supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Typical Funding Amounts

Average Grant Size

Total Number of Grants

2022 21,855

2023 21,722

2024 9,758

Top Grant Focus Areas

Funding Over Time

2022 $1,534,818,247

2023 $1,485,349,233 -3.22%

2024 $770,073,013 -48.16%

South Carolina Counties That Receive the Most Funding

100+
Available grants

$11.1M
Total funding amount

$11K
Median grant amount

2023 $1,485,349,233
-3.22%

2024 $770,073,013
-48.16%