South Carolina Infrastructure Funding via Appalachian Regional Commission
State and local agencies, local governing boards, nonprofits, tribes, and higher education institutions in eligible Appalachian counties of South Carolina can apply for Appalachian Regional Commission’s Area Development grants to support critical infrastructure and workforce or business development projects. Funding may benefit sustainability efforts through water and wastewater systems, transportation networks, broadband, and related public infrastructure improvements.
Appalachian Regional Commission
Community Well-Being Grants for Nonprofits via Triangle Community Foundation
South Carolina nonprofits focused on community well-being, youth enrichment, or education can access funding through the Triangle Community Foundation’s Clancy & Theys 1949 Fund. Eligible organizations in regions where Clancy & Theys operates may receive up to US $10,000 for programs that strengthen workforce development, youth programming, and access to healthcare, housing, and essential social services.
Triangle Community Foundation
Community Sustainability Funding for Nonprofits from First Horizon Foundation
Nonprofit organizations working on environmental sustainability and related community programs in select South Carolina counties can apply for grants supporting arts and culture, education, environmental initiatives, financial literacy, and health and human services. Focused on long-term community well-being, First Horizon Foundation funds eligible groups in Charleston, Greenville, Columbia, Spartanburg, and surrounding areas.
First Horizon Foundation
Foothills Community Foundation Grants in South Carolina
Nonprofit 501(c)(3) organizations in Anderson, Oconee, and Pickens Counties can seek Foothills Community Foundation’s unrestricted grants for one-time, high-impact projects. These South Carolina grants support pilot or catalytic efforts that address community problems, promote volunteer involvement, and can be sustained beyond the grant, and may benefit environmental conservation or sustainability initiatives.
Foothills Community Foundation
Community Programs Funding for Nonprofits from Levine Foundation
Nonprofit 501(c)(3) public charities with at least $500,000 in contributed revenue serving Carolinians can seek funding for education, healthcare, human services, and Jewish values programs. With a mission to foster lasting impact, Leon Levine Foundation provides support to organizations in South Carolina and North Carolina; sustainability-focused initiatives within these areas may be eligible.
Leon Levine Foundation
South Arts Grants for South Carolina Arts
With a mission to advance Southern vitality through the arts, South Arts provides South Carolina arts organizations with up to US $1,000 for professional development. Eligible small nonprofit arts groups and government or tribal arts units can fund conferences, workshops, staff training, and related travel or consultant costs that build organizational sustainability and capacity.
South Arts, Inc.
Gaylord & Dorothy Donnelley Foundation Arts Grants in South Carolina
Full proposal due Jul 31, 2026
Arts and cultural 501(c)(3) organizations or fiscally sponsored groups in South Carolina’s Lowcountry can receive multi-year general operating, capacity-building, and reserve challenge support for artistic work and organizational sustainability. Gaylord & Dorothy Donnelley Foundation funds artistically vital groups in Horry, Georgetown, Berkeley, Dorchester, Charleston, Colleton, Hampton, Jasper, and Beaufort counties that support professional and local artists.
Gaylord & Dorothy Donnelley Foundation
Blue Cross Foundation Support for South Carolina Health
Letter of inquiry due Aug 7, 2026
South Carolina health-focused nonprofits, government agencies, and tax-exempt educational or research institutions can access funding to improve health outcomes and expand care for economically vulnerable residents. Blue Cross and Blue Shield of South Carolina Foundation supports projects in areas like oral health, mental health, primary care, and community health initiatives that address systemic population health needs statewide.
Blue Cross and Blue Shield of South Carolina Foundation
Brown Family Foundation Grants for South Carolina Nonprofits
Letter of inquiry due Aug 10, 2026
Small 501(c)(3) nonprofits and local or state government units in South Carolina can seek funding for humanitarian, educational, health, and spiritual programs or projects. With a mission to improve lives, Brown Family Foundation provides $5,000 - $50,000 to initiatives with strong community engagement, measurable outcomes, and potential for lasting impact, which may include sustainability-related efforts.
Brown Family Foundation
Environmental and Community Funding from Community Foundation
Full proposal due Aug 14, 2026
South Carolina environmental and community nonprofits can access funding through Community Foundation for the Central Savannah River Area to support programs in conservation, health, education, arts, and human services. Eligible 501(c)(3)s and public entities serving Aiken and Edgefield counties may request up to US $15,000 for local projects addressing people in need, youth enrichment, or environmental initiatives.
Community Foundation for the Central Savannah River Area
Community Development Grants for Nonprofits from Jolley Foundation
Full proposal due Sep 1, 2026
South Carolina 501(c)(3) nonprofits working on arts, education, environment, health, or human services can seek project and capital funding that addresses poverty and discrimination. Focused on systemic, sustainable community change, the Jolley Foundation prioritizes Greenville County and upstate organizations, with awards of more than US $100,000 requiring a preliminary letter of inquiry.
Jolley Foundation
Yawkey Foundation Arts and Culture Grants
Pre proposal due Sep 18, 2026
Nonprofit 501(c)(3) organizations providing arts and culture programs in Georgetown County, South Carolina can apply for Yawkey Foundation Program and Small Capital Grants, with awards up to US $100,000 for discrete, timebound projects or equipment. Organizations working to enrich community culture and expand arts access may be eligible under the foundation’s priority areas.
Yawkey Foundation
Yawkey Foundation Grants for South Carolina Health
Pre proposal due Sep 18, 2026
Focused on health care access and delivery, Yawkey Foundation invites South Carolina nonprofits to request Program and Small Capital Grants for discrete, timebound projects or equipment needs. 501(c)(3) organizations serving Georgetown County with direct services in health care, children’s mental health, or health disparities may be eligible for awards up to US $100,000.
Yawkey Foundation
American Honda Motor Grants for South Carolina Sustainability
Applications due Nov 1, 2026
South Carolina environmental and sustainability-focused 501(c)(3) nonprofits and eligible schools can access funding through American Honda Motor for programs advancing decarbonization, clean energy, and efficient use of natural resources. Grants from US $25,000 - US $100,000 support initiatives like energy efficiency upgrades, solar or wind installations, recycling, composting, and other green infrastructure in Honda communities.
American Honda Motor Co., Inc.
Health Equity Grants for Carolinas Providers from Duke Endowment
Pre proposal due Nov 15, 2026
Eligible 501(c)(3) not-for-profit hospitals, academic health centers, area health education centers, inpatient facilities, and select organizations in counties without an eligible hospital in South Carolina can apply for health care funding to improve access and outcomes. The Duke Endowment supports projects in areas like access to care, maternal and infant health, mental health, oral health, and population health, which may benefit sustainability-focused community health initiatives.
The Duke Endowment
Duke Endowment Grants for South Carolina Families
Pre proposal due Dec 15, 2026
Nonprofit child- and family-serving agencies in South Carolina can seek funding to implement and sustain evidence-based programs that prevent or treat child abuse and neglect. With a mission to strengthen child and family well-being, The Duke Endowment provides support for implementation, innovation, and advocacy efforts serving children, youth, and families at risk.
The Duke Endowment
Yawkey Foundation Youth Athletics Grants in South Carolina
Letter of inquiry due Jan 23, 2027
Nonprofit 501(c)(3) organizations running youth baseball or softball programs and services in Georgetown County, South Carolina can receive up to US $100,000 for discrete program, small capital, or equipment needs. Yawkey Foundation provides South Carolina environmental conservation groups with opportunities when they also deliver direct youth and amateur athletics programming in its priority area.
Yawkey Foundation
US $250,000 - US $1,000,000
Strategic Growth Funding for Nonprofits from Yawkey Foundation
Letter of inquiry due Jan 23, 2027
Nonprofit 501(c)(3) organizations planning strategic growth or regional expansion, including those serving Georgetown County in South Carolina, can seek US $250,000 - US $1,000,000 to implement board-approved strategic initiatives. Yawkey Foundation supports high-impact work in conservation and wildlife, health, education, human services, youth athletics, and arts and culture through these multi-year Strategic Investment Grants.
Yawkey Foundation
South Carolina Education Funding via Foundation for Rural Service
Applications due Feb 15, 2027
Graduating high school seniors in rural North and South Carolina planning to attend college can receive $500 to $1,000 for tuition and related educational costs. Grants from Foundation for Rural Service help students who are U.S. citizens, sponsored by an NTCA member, and interested in returning to a rural community after graduation.
Foundation for Rural Service
Coastal Conservation Funding from South Carolina Sea Grant
Letter of inquiry due Feb 17, 2027
Faculty researchers at South Carolina Sea Grant Consortium member institutions in South Carolina can seek US $30,000 - US $80,000 for one- to two-year projects advancing coastal conservation, resilience, and sustainable development. With a mission to support environmental conservation, South Carolina Sea Grant funds work on fisheries, aquaculture, marine biology, oceanography, and related coastal sustainability topics.
South Carolina Sea Grant
South Carolina Conservation Funding via Yawkey Foundation
Letter of inquiry due Mar 20, 2027
Nonprofit 501(c)(3) organizations focused on environmental conservation and wildlife management in Georgetown County, South Carolina can seek Program and Small Capital Grants to support discrete, timebound program, project, or equipment needs. With a mission to invest in impactful nonprofits, Yawkey Foundation provides up to US $100,000 for work in its Conservation & Wildlife area of giving.
Yawkey Foundation
Education Access Funding from Yawkey Foundation
Letter of inquiry due Mar 20, 2027
Nonprofit 501(c)(3) organizations supporting college success and educational access for underserved young adults in Georgetown County, South Carolina can seek up to US $100,000 for timebound program or small capital needs. Focused on higher education access and persistence, Yawkey Foundation invites proposals for discrete projects, equipment, or program needs aligned with its education mission.
Yawkey Foundation
F. W. Symmes Foundation Support for Sustainability
Applications due Apr 1, 2027
Grants from F. W. Symmes Foundation help South Carolina 501(c)(3) organizations fund capital and program needs that benefit Greenville County residents, with awards of more than US $20,000. Environmental and conservation nonprofits working on sustainability, as well as groups in health, education, human services, arts, religion, and public benefit, may be eligible.
F. W. Symmes Foundation
BECU Foundation Sustainability Grants in South Carolina
Letter of inquiry due Apr 24, 2027
Nonprofit 501(c)(3) organizations working on sustainability and environmental conservation in South Carolina’s Charleston County can receive up to US $50,000 to support community-focused programs. BECU Foundation’s People Helping People Awards fund work such as conservation, stewardship, and broader efforts that strengthen local communities within BECU’s service areas.
BECU Foundation
Community Program Funding from Henry & Sylvia Yaschik Foundation
Applications due Apr 30, 2027
The Henry and Sylvia Yaschik Foundation provides South Carolina charitable organizations serving the greater Charleston area with one-time, multiyear, start-up, and challenge or matching grants. Qualified charities, including those running environmental conservation or other sustainability-related programs, may be eligible if they operate in the Charleston region and meet the foundation’s reporting and 501(c)(3) requirements.
Henry & Sylvia Yaschik Foundation
US $100,000 - US $200,000
South Carolina Parks Tourism Marketing Grants
Applications due Jun 5, 2027
Eligible 501(c) tourism marketing nonprofits in South Carolina can receive US $100,000 - US $200,000 to fund out-of-state advertising and promotional campaigns. South Carolina Department of Parks, Recreation & Tourism provides these reimbursable matching grants to highly developed emerging destinations, which may benefit communities working to grow sustainable, conservation-minded tourism and enhance local quality of life.
South Carolina Department of Parks, Recreation & Tourism
Community Foundation of Greenville Grants for Sustainability
Applications due Jul 17, 2027
South Carolina nonprofits with 501(c)(3) status can seek capacity building support to strengthen operations, governance, and long-term sustainability. Greenville County organizations may use Community Foundation of Greenville funding for planning, technology upgrades, management improvements, collaboration strategies, and feasibility studies that enhance their ability to serve the community and sustain impact.
Community Foundation of Greenville