South Dakota Community Development Funding via US Bancorp Foundation
South Dakota nonprofits working on economic advancement, affordable housing, or community arts and culture can access funding through US Bancorp Foundation to support programs that address racial and economic inequities. 501(c)(3) organizations in designated U.S. Bank communities, especially those led by people of color or advancing diversity, equity, and inclusion, may be competitive applicants.
US Bancorp Foundation
Costco Foundation Community Service Grants in South Dakota
Grants from Costco Foundation help South Dakota 501(c)(3) nonprofits fund community programs for children, education, and health and human services. Organizations conducting science-related education or health initiatives that benefit children or families may be eligible. Funding decisions consider documented community need, measurable outcomes, collaboration, and a broad base of financial support.
Costco Foundation
Creag Foundation Innovation Grants in South Dakota
Focused on innovative human services, the Creag Foundation invites South Dakota 501(c)(3) nonprofits to seek support for new approaches to social problems. Organizations with at least one year of tax-exempt status, including those advancing science-related human or environmental services, may be eligible to submit a letter of inquiry by invitation.
Creag Foundation
Youth and Science Programs Funding from DanPaul Foundation
501(c)(3) nonprofits conducting youth-focused programs, including science and research initiatives, can apply for the DanPaul Foundation’s grants, with awards up to US $15,000. Organizations in South Dakota may be eligible if their work advances the health, education, development, or welfare of children and youth worldwide, including scientific endeavors improving quality of life.
The Dan Paul Foundation
Draper Richards Kaplan Foundation Grants for Innovation
Early-stage, impact-first nonprofits and mission-driven for-profits working on scalable social or environmental solutions in South Dakota can access funding through Draper Richards Kaplan Foundation, with awards up to US $300,000 over three years. Organizations conducting applied science or research-based interventions that directly benefit underserved communities may be competitive applicants.
Draper Richards Kaplan Foundation
Tech-Enabled Social Impact Funding from Cisco
Nonprofit and NGO programs using technology for crisis response, education access, or economic empowerment, including those serving South Dakota, can seek Global Impact Cash Grants to tackle critical social challenges. Cisco Systems Foundation prioritizes innovative, early-stage, tech-enabled solutions for underserved communities worldwide, with awards up to US $100,000 and applications accepted year-round via an initial LOI.
Cisco Systems Foundation
Safety and Education Grants for Nonprofits from State Farm Companies Foundation
South Dakota educational institutions, government programs, 501(c)(3) nonprofits, and volunteer fire companies can access funding through State Farm Companies Foundation to support safety, education, and community development initiatives. Projects may include disaster preparedness, auto and home safety, K–12 or higher education, STEM programs, job training, financial literacy, affordable housing, and neighborhood revitalization that could complement science-related work.
State Farm Companies Foundation
South Dakota Social Service Funding via Hearst Foundation
South Dakota nonprofits providing direct social services that address chronic poverty and strengthen families can access funding through William Randolph Hearst Foundation for program, capital, or general support. U.S.-based 501(c)(3) organizations with audited expenses over $2 million and strong, scalable outcomes may be eligible for grants of more than US $100,000.
William Randolph Hearst Foundation
South Dakota Community Health Funding via Labcorp
Nonprofit and equivalent charitable organizations working in health, education, or community services in South Dakota can access funding via Labcorp Charitable Foundation to support programs like healthcare for underserved populations, food pantries, and STEM education. Science and health research initiatives that fit these priorities, including preventative healthcare and patient services, may be eligible.
Labcorp Charitable Foundation
Michael & Susan Dell Foundation Education Grants in South Dakota
Organizations such as nonprofits, social enterprises, schools, and government entities in South Dakota working on education or children’s health can apply for Michael & Susan Dell Foundation grants; awards are More than US $50,000 for project support or scaling. Eligible projects must serve urban low-income children or youth in the U.S., India, or South Africa and align with the foundation’s values.
Michael & Susan Dell Foundation
NorthWestern Energy Community Grants in South Dakota
Nonprofit organizations with 501(c)(3) or 170(c)(2) status in South Dakota counties served by NorthWestern Energy can seek funding for education, health and human services, civic projects, culture and the arts, and resource conservation. With a mission to build stronger communities, NorthWestern Energy provides monetary support for programs, equipment, and facility improvements.
NorthWestern Energy
Science and Education Funding for Charities from Roche
Focused on science and education, this corporate philanthropy program invites accredited charities to propose innovative projects that promote sustainable development and can leverage Roche’s scientific expertise and logistics capabilities. Eligible organizations in South Dakota may be able to access support for youth science education, health-related research outreach, or community-focused STEM initiatives through local Roche affiliates.
La Roche, Inc.
Health and Human Services Funding from Semnani
Nonprofit and humanitarian organizations conducting health, education, or disaster relief programs for marginalized communities worldwide, including South Dakota, can apply for support from the Semnani Family Foundation. Grants may benefit projects in areas like health care access, disease prevention, child and women’s health, literacy, and broader human and social services that intersect with scientific or health-related research.
Semnani Family Foundation
Sidney Stern Memorial Trust Grants for Science
With a mission to support charitable, scientific, medical, and educational work, Sidney Stern Memorial Trust provides South Dakota science organizations and other 501(c)(3) nonprofits with funding for U.S.-based programs. Eligible tax-exempt organizations conducting chemistry, biology, physics, or related research in the U.S. may be strong candidates.
Sidney Stern Memorial Trust
South Dakota Human Services Funding via Gupta Family Foundation
Applications due Jul 31, 2026
Non-sectarian human and social service nonprofits helping disadvantaged people become self-reliant can apply for US $5,000 - US $250,000 in project or program support, including work in South Dakota. With a mission to expand opportunity, Gupta Family Foundation provides smaller 501(c)(3)s and qualifying foreign entities with grants for poverty alleviation, disability services, and humanitarian relief that may intersect with science-related initiatives.
Gupta Family Foundation
Cowles Charitable Trust Support for Research
Applications due Sep 1, 2026
U.S. 501(c)(3) charitable organizations conducting education, health, or climate-related research can apply for Cowles Charitable Trust grants of up to US $10,000. Projects in scientific fields like biology or earth science may be eligible, with a preference for work in Downstate New York and South Florida and for organizations seeking general operating support.
Cowles Charitable Trust
Hansen Family Foundation Education Grants in South Dakota
Applications due Sep 11, 2026
South Dakota 501(c)(3) nonprofits conducting education, youth, environmental, or humanitarian programs can apply for Hansen Family Foundation grants of US $1,000 - US $10,000. Organizations with science education or research-related outreach, especially those serving children or advancing environmental understanding, may be eligible if they are U.S.-based and meet the foundation’s size and overhead limits.
Hansen Family Foundation
Southern Science and Education Funding via Robinson Foundation
Applications due Oct 15, 2026
Southern 501(c)(3) organizations conducting education or health-related science work can access funding through Robinson Foundation if they serve communities below the Mason-Dixon line. Grants support single-year projects in areas like medical assistance, education, environmental conservation, and disaster relief, which may benefit South Dakota partners working collaboratively in these fields.
Robinson Foundation
Dudley T Dougherty Foundation Support for Science
Applications due Oct 31, 2026
Nonprofit 501(c)(3) organizations conducting community-focused or environmental science work in South Dakota may be eligible for funding that supports research and related programs. Focused on community services, environmental conservation, and peacebuilding, the Dudley T Dougherty Foundation invites proposals that advance understanding, stewardship, and well-being in a changing world.
Dudley T Dougherty Foundation Inc
Youth and Basic Needs Grants from TJX Foundation
Letter of inquiry due Oct 31, 2026
Nonprofit 501(c)(3) organizations supporting basic needs, at-risk youth education, workforce readiness, or safety from domestic violence near TJX locations, including South Dakota, can seek program funding. The TJX Foundation invites eligible groups to complete an online eligibility questionnaire, then a Letter of Inquiry, with full applications accepted by invitation only.
The Tjx Foundation Inc
Lawrence Foundation Support for Environmental Programs
Applications due Nov 1, 2026
Nonprofit 501(c)(3) organizations, public schools, and libraries conducting environmental or human services work in South Dakota can seek unrestricted program or operating support from the Lawrence Foundation, with typical awards of US $5,000 - US $10,000. With a mission to support environmental and human services causes, the foundation welcomes applications that may include science-related environmental research or conservation projects.
Lawrence Foundation
Max and Victoria Dreyfus Foundation Grants for South Dakota Community Programs
Applications due Nov 11, 2026
Max and Victoria Dreyfus Foundation provides South Dakota nonprofit organizations with grants of US $1,000 - US $20,000 for museums, cultural and performing arts, education, health facilities, environmental and wildlife protection, and community services. U.S.-based 501(c)(3) groups conducting science-related education or community programs may be eligible if a relatively small award would have significant impact.
Max and Victoria Dreyfus Foundation
Ameriprise Financial Support for Community Vitality
Applications due Jan 15, 2027
Nonprofit 501(c)(3) organizations working on basic needs, community development, cultural enrichment, or volunteer-driven programs in the U.S., including South Dakota, may be eligible for Ameriprise Financial Community Grants. Focused on hunger, housing, adult self-sufficiency, and community vitality, these grants prioritize measurable outcomes, financial stability, and strong engagement from Ameriprise employee and advisor volunteers.
Ameriprise Financial
Health Information Training Grants from National Library of Medicine
Applications due Feb 21, 2027
Individuals and institutions affiliated with NNLM Region 4 member libraries, including those in South Dakota, can apply for National Library of Medicine professional development awards of US $2,500 to build skills in health information access, data science, and related areas. Funding supports workshops, conferences, courses, speakers, and other training that enhance health information services for underrepresented communities.
National Library of Medicine
O'Reilly Automotive Foundation Grants for South Dakota Communities
Applications due Apr 15, 2027
Nonprofit 501(c)(3) organizations improving economic stability, workforce readiness, health, social services, or disaster relief in South Dakota communities where O’Reilly Auto Parts operates can seek project, operating, or capital support. Grants from O'Reilly Automotive Foundation help community-focused groups, including those with science or health-related research components, strengthen quality of life for underserved residents.
O'Reilly Automotive Foundation Inc
Chick Fil A Foundation Grants for Youth
Applications due May 1, 2027
South Dakota nonprofits supporting youth education, basic needs, housing, or environmental programs can access funding through Chick Fil A Foundation’s True Inspiration Awards. Eligible 501(c)(3) organizations may receive US $30,000 - US $350,000 for initiatives such as academic enrichment, food security, family services, community development, or environmental stewardship, including garden and outdoor learning projects.
Chick Fil A Foundation Inc
Community Partnership Grants for Nonprofits from Mutual of America Foundation
Applications due Jul 1, 2027
U.S. nonprofit organizations leading strong, replicable community partnerships, including those in South Dakota and potentially involving science research collaborations, can apply for Mutual of America Foundation’s national Community Partnership Award. Funding recognizes exemplary cross-sector partnerships that measurably improve communities, model effective collaboration, and inspire innovative approaches to significant social issues.
Mutual Of America Foundation