Community Development Funding from US Bank Foundation
501(c)(3) nonprofits in Iowa working on economic and workforce advancement, safe and affordable housing, or community arts and culture can apply for the U.S. Bank Foundation’s Community Possible Grant Program. Organizations addressing work, home, and play, especially those led by a person of color and advancing equity, may be eligible to support health- or rare-disease-related community needs.
US Bancorp Foundation
Costco Foundation Grants for Iowa Health Programs
Nonprofit 501(c)(3) organizations in Iowa that support children, education, or health and human services can seek monetary program funding, which may include rare disease initiatives, from the Costco Foundation. Focused on measurable community impact and collaboration, applicants should demonstrate clear needs, evidence-based outcomes, and a broad base of financial support.
Costco Foundation
Creag Foundation Human Services Grants in Iowa
Nonprofit 501(c)(3) organizations with innovative human services or health-related programs in Iowa can seek support for new approaches to social problems. Creag Foundation supports creative solutions across areas like diseases and conditions, health care access, and community services; interested groups may submit a letter of inquiry for invitation-only funding consideration.
Creag Foundation
Draper Richards Kaplan Support for Scalable Innovation
Early-stage nonprofit and impact-first for-profit organizations tackling major social or environmental challenges in Iowa and beyond can access funding and intensive capacity-building support through Draper Richards Kaplan Foundation. Grants up to US $300,000 over three years back scalable, systems-focused solutions benefiting underserved communities, which may include innovative rare disease or respiratory health initiatives.
Draper Richards Kaplan Foundation
Iowa Tech-Enabled Community Funding via Cisco
Nonprofit and NGO programs using technology for crisis response, education access, or economic empowerment in Iowa and worldwide can apply for Cisco Systems Foundation’s Global Impact Cash Grants, offering up to US $100,000 for innovative, early-stage solutions. Organizations serving mostly economically underserved communities, including those addressing rare or chronic disease impacts, may be eligible.
Cisco Systems Foundation
State Farm Foundation Support for Community Safety
Educational institutions, government programs, 501(c)(3) nonprofits, and 501(c)(4) volunteer fire companies in Iowa can seek funding for safety, education, and community development initiatives. With a mission to strengthen communities, State Farm Companies Foundation provides support for projects like disaster preparedness, community revitalization, financial literacy, and K–12 or higher education programs that may benefit people with rare diseases.
State Farm Companies Foundation
William Randolph Hearst Foundation Grants for Cultural Programs
Nonprofit cultural institutions in the U.S. can seek more than US $100,000 to support arts, science, and arts education programs through the William Randolph Hearst Foundation. Grants from William Randolph Hearst Foundation help Iowa organizations with performing arts, museums, STEAM education, and artist development that demonstrate broad impact and strong sustainability.
William Randolph Hearst Foundation
Health and Community Funding from Labcorp Charitable Foundation
Nonprofit and charitable-equivalent organizations working on health, education, or community programs in Iowa can apply for support that may include healthcare access, food pantries, STEM education, or wellness initiatives. Focused on community health and welfare, Labcorp Charitable Foundation invites projects that could benefit people affected by rare or chronic respiratory diseases.
Labcorp Charitable Foundation
Michael & Susan Dell Foundation Grants for Education
Iowa organizations working on education, children’s health, or family economic stability for urban low-income youth can access funding through the Michael & Susan Dell Foundation for project support or scaling efforts. Eligible applicants include nonprofits, social enterprises, schools, governments, and other entities requesting more than US $50,000, with projects based in the U.S., India, or South Africa.
Michael & Susan Dell Foundation
Humanitarian and Education Funding from Roche
Accredited charities in Iowa and other countries can seek support for humanitarian, social development, science education, community, environmental, and contemporary arts projects that engage Roche expertise and employees. Grants from Roche help organizations whose programs may include rare or respiratory disease-related services, provided they are non-commercial and not tied to political, religious, or image-building purposes.
La Roche, Inc.
Iowa Health Access Funding via Semnani Family Foundation
Nonprofit organizations providing health care, disease-related services, or humanitarian aid in Iowa can access funding through Semnani Family Foundation, which supports health, education, and disaster relief worldwide. Programs serving marginalized or vulnerable populations, including those affected by complex or rare conditions, may be eligible under its broad human welfare focus.
Semnani Family Foundation
Health and Education Funding from Sidney Stern Memorial Trust
Iowa 501(c)(3) nonprofits working in health, medical research, education, or related charitable services can access funding through the Sidney Stern Memorial Trust for programs serving people in the U.S. Eligible projects should be well-managed, have broad impact on their target populations, and materially contribute to general welfare, including work connected to respiratory or rare diseases.
Sidney Stern Memorial Trust
Bank of America Foundation Grants for Iowa Communities
With a mission to strengthen communities, Bank of America Charitable Foundation provides Iowa nonprofits with sponsorship support for community development, basic needs, workforce education, and cultural programs. U.S. 501(c)(3) organizations, including those addressing health-related or rare disease impacts through housing, hunger relief, or inclusive community initiatives, may be eligible to apply.
Bank Of America Charitable Foundation Inc
Gupta Family Foundation Support for Human Services
Applications due Jul 31, 2026
Non-sectarian nonprofits helping disadvantaged people become self-reliant can receive US $5,000 - US $250,000 for human and social services, poverty alleviation, disability support, or disaster relief worldwide. Focused on smaller organizations, Gupta Family Foundation invites eligible 501(c)(3)s, including those serving Iowa communities through broader programs, to apply if they meet its mission and revenue criteria.
Gupta Family Foundation
Hansen Family Foundation Support for Community Programs
Applications due Sep 11, 2026
Iowa nonprofits with 501(c)(3) status seeking support for children, education, humanitarian aid, animals, environment, or arts and culture can access funding through Hansen Family Foundation, with awards ranging from US $1,000 - US $10,000. U.S.-based organizations worldwide, including those addressing rare disease impacts within these causes, may be considered if budgets are under $1 million and overhead under 25%.
Hansen Family Foundation
Health and Human Services Funding from Robinson Foundation
Applications due Oct 15, 2026
Nonprofit 501(c)(3) organizations serving health, medical assistance, or humanitarian needs in the Southern U.S. can seek support for programmatic work from the Robinson Foundation. Focused on relieving hardship, it invites established charities (3+ years) addressing issues like poverty relief, disaster response, or family and youth services, which may include rare disease initiatives in Iowa’s southern communities.
Robinson Foundation
Iowa Community and Environment Funding via Dudley T Dougherty Foundation
Applications due Oct 31, 2026
Iowa nonprofits with 501(c)(3) status seeking support for community services, environmental conservation, or peacebuilding can access funding through the Dudley T Dougherty Foundation. Organizations working on rare disease challenges that intersect with community well-being or environmental health may be eligible under this broad, change-focused philanthropic program.
Dudley T Dougherty Foundation Inc
Community Programs Funding for Nonprofits from Georgia-Pacific Foundation
Applications due Oct 31, 2026
Iowa 501(c)(3) nonprofits, public schools, and qualified local government entities can access funding for education, environment, entrepreneurship, and community enrichment projects that serve communities near Georgia-Pacific facilities. Georgia-Pacific Foundation prioritizes organizations within 30 miles of a GP manufacturing community whose programs strengthen long-term well-being and sustainability, which may include initiatives benefiting people with rare or respiratory diseases.
Georgia-Pacific Foundation
Iowa Youth and Basic Needs Funding via TJX Foundation
Letter of inquiry due Oct 31, 2026
Nonprofit 501(c)(3) organizations in Iowa working on basic needs, youth education, workforce readiness, or domestic violence services can seek program support if located within 15 miles of a TJX site. With a mission to help vulnerable families and children build better futures, TJX Foundation provides invitation-only grants following an eligibility questionnaire and Letter of Inquiry process.
The Tjx Foundation Inc
Lawrence Foundation Support for Community Services
Applications due Nov 1, 2026
Nonprofit 501(c)(3) organizations, public schools, and libraries seeking support for environmental or human services programs in Iowa can apply for unrestricted grants ranging from US $5,000 - US $10,000. Lawrence Foundation funds general operating or project costs for U.S.-headquartered groups, which may include organizations addressing rare or respiratory diseases within its broad priorities.
Lawrence Foundation
Max and Victoria Dreyfus Community Grants in Iowa
Applications due Nov 11, 2026
Nonprofit organizations in Iowa seeking support for community-based programs can apply for grants of US $1,000 - US $20,000 to fund education, cultural, health, environmental, and social services initiatives. With a mission to strengthen impactful organizations, Max and Victoria Dreyfus Foundation provides U.S. nonprofits with flexible project or program funding that may benefit rare disease–related services and facilities.
Max and Victoria Dreyfus Foundation
Community Vitality Funding from Ameriprise Financial
Applications due Jan 15, 2027
Iowa 501(c)(3) nonprofits working on basic needs, community development, or volunteer-driven programs can access funding through Ameriprise Financial to support hunger relief, shelter, adult self-sufficiency, and cultural enrichment initiatives. Organizations must serve U.S. communities, show measurable outcomes and financial stability, and are strongest candidates when Ameriprise employees or advisors are actively engaged as volunteers.
Ameriprise Financial
Dr Scholl Foundation Support for Health Programs
Letter of inquiry due Jan 31, 2027
Nonprofit 501(c)(3) organizations can seek project funding for education, health care, social services, environmental, civic, and cultural initiatives through the Dr Scholl Foundation, primarily serving U.S. communities including Iowa. Focused on broad community impact, this grant may benefit programs addressing rare or respiratory diseases within those eligible categories.
Dr Scholl Foundation
O'Reilly Automotive Foundation Community Grants in Iowa
Applications due Apr 15, 2027
Nonprofit 501(c)(3) organizations in Iowa communities served by O’Reilly Auto Parts can seek funding for programs improving economic stability, workforce development, health and social services, and disaster relief. O'Reilly Automotive Foundation offers project, general operating, and capital support to U.S.-based charities benefiting underserved and underrepresented individuals and families.
O'Reilly Automotive Foundation Inc
Community Programs Funding from Union Pacific Foundation
Applications due Apr 30, 2027
Nonprofit 501(c)(3) organizations in Iowa can apply for Union Pacific Foundation’s Community Ties Local Grants, awarding US $5,000 - US $30,000 for safety, workforce development, community vitality, and environmental sustainability projects. Health and community organizations serving people with rare or respiratory diseases may be eligible if their programs fit these priority areas in Union Pacific–served communities.
Union Pacific Foundation
Chick Fil A Foundation Support for Community Programs
Applications due May 1, 2027
Nonprofit 501(c)(3) organizations and equivalent charities with youth, family, food security, housing, or environmental programs can apply for the True Inspiration Awards in Iowa and beyond. With a mission to celebrate impactful community work, Chick Fil A Foundation provides grants of US $30,000 - US $350,000 to support and expand these initiatives, which may benefit rare disease populations indirectly.
Chick Fil A Foundation Inc
Iowa Nonprofit Partnership Funding via Mutual of America Foundation
Applications due Jul 1, 2027
Nonprofit organizations in Iowa with strong, replicable community partnerships addressing significant social issues can apply for national recognition and support through the Community Partnership Award. Mutual of America Foundation supports collaborative U.S. nonprofits; Iowa groups working on rare or respiratory diseases within broader community initiatives may be competitive.
Mutual Of America Foundation