Best South Carolina Grants for Nonprofits

The Area Development Grant Program, managed by the Appalachian Regional Commission (ARC), supports economic growth in Appalachia through investments in critical infrastructure and workforce development. Targeting 423 counties across 13 states, the program encourages local communities to collaborate with state governments to identify and implement impactful projects. Key focus areas include enhancing utilities, promoting entrepreneurship, and strengthening local leadership. This initiative aims to uplift the 26 million residents of Appalachia, fostering sustainable economic opportunities.

The Auto Club Group Foundation focuses on creating a positive impact through grants that enhance traffic safety, driver education, and financial literacy across 14 U.S. states and two territories. With a mission rooted in community service, the foundation supports nonprofit organizations and government entities that align with its goals. Grants typically range from $5,000 to $15,000, addressing crucial areas such as traffic safety initiatives, financial literacy for K-12 students, and equitable access to driver education programs.

CSX Charitable Investments provide essential in-kind donations to nonprofit organizations focused on supporting military members and community first responders. Through intermodal transportation services, CSX offers equipment and rail services to help reduce transportation costs for eligible organizations. The program also includes occasional donations of railroad materials and equipment based on availability. CSX prioritizes support for organizations operating within its service areas, promoting community betterment and development.

The First Horizon Foundation, established by First Horizon National Corp., supports communities in Florida, North Carolina, and South Carolina. Since 1993, it has donated over $90 million to enhance lives through grants focused on arts, education, environment, financial literacy, and health services. Eligible nonprofits in various cities can apply, while individuals and certain organizations, such as K-12 schools and political groups, are excluded from funding. This foundation is dedicated to making a positive impact in the regions it serves.

Honda’s Community Event Sponsorship aims to support local, regional, and national events that enhance community engagement and celebrate diverse cultures. Organizations must be U.S.-based and tax-exempt, focusing on projects that serve communities where Honda associates are active. Eligible events include parades, festivals, and educational initiatives. Honda evaluates requests based on community needs and available funding, reinforcing its commitment to social responsibility and community enhancement.

The Leon Levine Foundation, established in 1980, focuses on enhancing the human condition through investments in education, healthcare, and human services in North and South Carolina. The foundation seeks nonprofits with proven leadership and sustainable financial plans. They aim to create pathways to self-sufficiency and promote lasting change. LOIs are accepted year-round, and grant recipients must support an inclusive environment free from discrimination.

The Makulinski Family Foundation Grant supports nonprofit and charity organizations, emphasizing sustainable community development. With a commitment to lasting change, MFF actively matches investments to amplify their impact, ranging from 10:1 to 1:2 based on beneficiary needs. The foundation welcomes proposals from various regions, including Ohio, Michigan, and South Carolina, and encourages applications that align with their mission. Interested parties can access the grant request form to submit their proposals.

The Southern Partners Fund's Discretionary Fund Grant aims to support grassroots community organizing for social, economic, and environmental justice in the Southeastern United States. It provides financial resources and technical assistance to rural organizations and leaders focused on transformative change. Eligible applicants include self-governed rural groups engaging in advocacy and community development. The fund prioritizes education reform, immigration rights, and voter engagement, allowing up to two requests per year, with a maximum award of $3,500.

BECU Foundation invites year-round sponsorship requests from organizations in Washington, Oregon, Idaho, and South Carolina. There are no limits on the funding amount, and larger requests may require additional information. The foundation supports community-focused events, including festivals and parades, aligning with its core values. Please note that requests related to fundraising events, schools, or any form of religious or political activity are ineligible for funding.

The Corporate Giving Program by the Franklin P. and Arthur W. Perdue Foundation focuses on supporting nonprofit organizations within specific states. They prioritize initiatives that enhance community welfare, especially in agriculture, education, health, and environmental sustainability. Organizations must have 501(c)(3) status to apply, and preference is given to those involving Perdue associates. Ineligible requests include those from religious, political, or individual-focused groups. This program emphasizes broad community benefits over organizational affiliations.

Truist Foundation

The Truist Foundation is committed to Truist Financial Corporation's (NYSE: TFC) purpose to inspire and build better lives and communities. Established in 2020, the foundation makes strategic investments in nonprofit organizations to help ensure the communities it serves have more opportunities for a better quality of life. The Truist Foundation's grants and activities focus on building career pathways to economic mobility and strengthening small businesses.

Inspire Awards

This year’s Inspire Awards seeks nonprofits supporting the career navigation and workforce development needs of workers across the United States. The challenge seeks applications that help individuals gain the skills, guidance, and support needed to access quality jobs, advance in their careers, and build long-term stability in an evolving world of work.

2026 Truist Foundation Inspire Awards Challenge Question

How are nonprofits providing innovative direct services, training programs, and career navigation supports for adult workers in the age of AI?

Challenge Dimensions

Nonprofit organizations have long been critical advocates and service providers for workers in the United States. Nonprofits provide workers necessary upskilling opportunities, AI literacy training, career navigation support, and wraparound services in conjunction with career pathways programming. All necessary for the modern workforce. Meeting the moment, Truist Foundation and MIT Solve want to hear the ways in which nonprofits headquartered in the Truist operating footprint are providing innovative career pathway programming in the age of AI. Although solutions don’t need to focus on generative AI specifically, teams should demonstrate how their career pathways programming align with the following dimensions:

• Training and Upskilling Programs – Providing holistic, accessible programming that equips workers with essential skills, industry-validated credentials, and technical literacy for the modern workplace.
• AI Readiness and Literacy – Offering high-quality training that helps workers understand generative AI and agentic technologies as augmented intelligence tools, helping to build practical skills like effective prompting, domain expertise application, and ethical use.
• Additional Wraparound Services and Basic Needs Support – Supporting unemployed and underemployed workers on their journey to economic mobility through comprehensive, integrated resources including childcare, transportation support, mentorship, mental health services, benefits navigation, and more.
• Career Navigation in the AI Economy – Enabling workers to navigate career choices with clarity and confidence by providing accessible information about how AI is reshaping job roles and industries, facilitating informed decisions about high-quality career trajectories that align with individual circumstances, and connecting workers to industry-validated credentials or trainings.

Here are the grants for this challenge

• First place: $250,000
• Second place: $150,000
• Runners-up: $25,000
• Audience favorite: $75,000

The BlueCross BlueShield of South Carolina Foundation's Health Priority Grants support initiatives that enhance health access and outcomes for South Carolinians, especially the economically disadvantaged. Established in 2003, the Foundation aims to bridge health and healthcare gaps through innovative partnerships. Eligible applicants include nonprofits with 501(c)(3) status and government agencies. The Foundation prioritizes projects addressing oral health and mental health, among other systemic health issues, to create sustainable, data-driven solutions.

The Philip L. Van Every Foundation provides grants to 501(c)(3) organizations in North and South Carolina, focusing on education, healthcare, human services, and the arts. With a commitment to strengthen communities and support fiscal responsibility, the foundation aims to enhance lives through meaningful projects. Organizations must demonstrate a track record of success to be eligible for funding, which is generally awarded for special projects and capital needs.

Dabo's All in Team Foundation Grant Program aims to support local South Carolina organizations in need of financial assistance for projects that align with its mission to address critical education and health issues. By providing funding opportunities, the program seeks to empower organizations with innovative solutions that can positively impact their communities. This initiative fosters collaboration among groups dedicated to improving lives across the state, ensuring that valuable ideas receive the support they deserve.

The Baltimore Life Community Grants Program, established by the Baltimore Life Foundation, awards grants of up to $500 to nonprofit organizations in various states, including Maryland and Virginia. This initiative aims to enhance community quality of life through projects that focus on family safety and community enhancement. Eligible applicants must be IRS-certified 501(c)(3) organizations, with priority given to those with volunteer support. This program reflects Baltimore Life's commitment to corporate citizenship and community involvement.

The Food Lion Feeds Charitable Foundation, established in 2001, has awarded over $17.5 million to combat hunger in its operating areas. This foundation focuses on supporting children at risk of hunger and enhancing the capacity of feeding agencies to provide nutritious meals. They also emphasize nutrition education to mitigate health risks associated with hunger. Eligible organizations include 501(c)(3) nonprofits located within 20 miles of a Food Lion store, with applications accepted annually.

The Corporate Giving Program by the Franklin P. and Arthur W. Perdue Foundation supports nonprofit organizations that enhance community welfare. Focus areas include agriculture, education, fighting hunger, and public safety. Eligible applicants must have IRS 501(c)(3) status and a Taxpayer Identification number. Requests are prioritized for programs directly benefiting communities near Perdue facilities across various states. The foundation emphasizes responsible stewardship and community engagement in all funding decisions.

The J. Bulow Campbell Foundation, established in 1940, focuses on grantmaking in Atlanta and Georgia, prioritizing capital projects in education, youth development, human services, public spaces, and cultural institutions. With a legacy of over $800 million awarded, the Foundation reflects the values of its founder, J. Bulow Campbell, emphasizing careful stewardship and Christian principles. While open to neighboring states, grants are generally restricted to tax-exempt institutions, excluding individuals and certain funding purposes.

The Fund for Southern Communities Grant supports grassroots social change organizations in North Carolina, South Carolina, and Georgia. Established in 1981, this foundation offers grants and technical assistance to groups fighting discrimination, promoting worker rights, and advocating for environmental protection. Eligible organizations must be registered non-profits with 501(c)(3) tax status. The Fund prioritizes groups with budgets of $150,000 or less focused on long-term social change.

The ARISE Grants, offered by the Appalachian Regional Commission, aim to drive regional economic transformation across 13 Appalachian states. With funding of up to $63.5 million for implementation grants and $10 million maximum awards, the initiative supports collaborative projects that enhance community capacity and economic growth. The program encourages innovative partnerships to strengthen local economies and achieve socioeconomic parity, benefiting over 26 million residents in the Appalachian Region.

The American Honda Foundation provides programmatic support to nonprofit organizations and schools in the U.S., empowering impactful initiatives aligned with community needs. Funding opportunities are available through Honda corporate and Honda USA Foundation, focusing on projects that enhance education and community welfare. Eligible organizations must have nonprofit status or be recognized educational institutions. The application process opens each fall, with funding decisions announced the following spring, ensuring alignment with Honda's commitment to social responsibility.

The Programmatic Support - Education Pillar Award by Honda aims to enhance workforce readiness in the manufacturing sector. It supports nonprofit organizations and schools focused on hands-on programs in design, software/data analytics, and AI/machine learning. Eligible applicants must be US-based and have 501(c)(3) status. The initiative prioritizes projects that train individuals for manufacturing roles, develop technical skills, and introduce automation to prepare for evolving industry demands, ultimately fostering economic prosperity in local communities.

Midlands Gives, initiated by the Central Carolina Community Foundation, unites the Midlands community to support local nonprofits across 11 counties. Established in 2014, this campaign not only raises awareness but also amplifies donations through an 18-hour online giving challenge held every May. Since its inception, it has successfully raised over $9.3 million, providing nonprofits with a vital platform for outreach and donor engagement, helping them thrive and enhance community welfare.

The BECU Foundation's People Helping People Awards honor exceptional nonprofit work in communities served by BECU. Each year, BECU members can nominate organizations for grants up to $50,000. Eligible nonprofits must be active 501(c)(3) organizations with a direct impact in Idaho, Oregon, South Carolina, or Washington. This initiative highlights the importance of community service and encourages members to recognize local heroes making a difference.

The Hubert E. Sapp Regular Grant Cycle, by Southern Partners Fund, aims to empower rural communities in the Southeastern U.S. through grassroots leadership and organizing. The fund provides support to nonprofit organizations focused on social, economic, and environmental justice. Eligible applicants are community-based organizations with budgets under $350,000. The initiative honors Hubert E. Sapp's legacy, promoting equitable relationships that drive real transformation and community decision-making.

The AmeriHealth Caritas Foundation Grant aims to prevent and mitigate adverse childhood experiences (ACEs) to promote healthier outcomes for children. With a focus on empowering families, healing behaviors, and access to healthcare, the foundation supports nonprofit organizations that provide comprehensive care and resources. Grants range from $100,000 to $250,000, totaling up to $1.945 million for project-specific initiatives. Eligible organizations must be 501(c)(3) nonprofits operating in states where AmeriHealth Caritas Medicaid markets exist.

The Yawkey Foundation offers Program and Small Capital Grants to nonprofit organizations making meaningful impacts in Health Care, Education, Human Services, Youth and Amateur Athletics, Arts and Culture, and Conservation and Wildlife. Grants can be up to $100,000 and support projects aligned with the nonprofit’s mission. Organizations are encouraged to submit Initial Proposals during designated periods, demonstrating strong leadership and community impact, particularly in underserved regions of Eastern Massachusetts.